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Do not take any more doses of sildenafil or similar medications such as tadalafil (Cialis) or vardenafil (Levitra) until you talk to your doctor. For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, VIAGRA may be taken anywhere from 30 minutes to 4 hours before sexual activity. Sildenafil causes mild and transient decreases in blood pressure which, in the majority of cases, do not translate into clinical effects. The mean maximum decreases in supine systolic blood pressure following 100 mg oral dosing of sildenafil was 8.4 mmHg. The corresponding change in supine diastolic blood pressure was 5.5 mmHg.

If the drug doesn’t work for you, you shouldn’t take another dose until at least 24 hours later. And talk with your doctor if you feel Viagra isn’t helping to treat your ED. They may recommend that you try a different medication for your ED. Usually, an erection goes away when PDE5 breaks down the cyclic GMP in your penis. But Viagra blocks the action of PDE5, so it allows cyclic GMP to keep working for a longer period of time than usual. This action improves blood flow to your penis and helps you get and keep an erection.

Caution is advised when PDE5 inhibitors are co-administered with alpha-blockers. PDE5 inhibitors, including VIAGRA, and alpha-adrenergic blocking agents are both vasodilators with blood pressure lowering effects. When vasodilators are used in combination, an additive effect on blood pressure may occur. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you.

Some experts recommend taking Viagra on an empty stomach, while the prescribing information notes that Viagra can be taken with or without food. Either way, both agree that you should not take Viagra after a high-fat meal. If you’re taking Viagra regularly, it may be a good idea to keep track of what works best for you. Luckily, most men experience no side effects when they take Sildenafil or Tadalafil. If sildenafil 50mg has worked, but you have experienced side effects, sildenafil 25mg can provide the same effect, with a lower chance of side effects. Most people who have taken Viagra will eventually turn to sildenafil, as it is a cheaper option that provides the same results.

Avanafil is the active ingredient in Spedra tablets which tackles ED. It is a PDE-5 inhibitor — a drug that increases the blood flow to your penis once you have become aroused. This blood flow will only occur during sexual stimulation