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The major circulating metabolite results from N-demethylation of sildenafil. This metabolite has a phosphodiesterase selectivity profile similar to sildenafil and an in vitro potency for PDE5 approximately 50% that of the parent drug. Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil. The N-desmethyl metabolite is further metabolised, with a terminal half-life of approximately 4 h. When sildenafil is taken with food, the rate of absorption is reduced with a mean delay in tmax of 60 minutes and a mean reduction in Cmax of 29%. In cases of overdose, standard supportive measures should be adopted as required.

Common psychological causes of ED include stress, anxiety, and depression. Often there are several factors causing erectile dysfunction, not just a single cause. For more information, read our doctors’ advice on the causes of erectile dysfunction. Generic Viagra from Canada can be attributed to the second price category.

You will be charged for the online visit as soon as it is approved by the healthcare practitioner. From there, and after your prescription is activated by the pharmacy, you will be charged the medication cost for each shipment based on your chosen refill schedule. If you have provided insurance or benefits coverage details, it will be applied according to your plan. Felix is Canada’s first truly integrated healthcare platform. We provide on-demand treatment for everyday health needs like weight loss, mental health, sexual health, and more.

After Pfizer’s patent for Viagra expired in 2013, sildenafil (the active ingredient in Viagra) was made more widely available for manufacturing by other companies. Nowadays, many manufacturers continue to make sildenafil as a blue-coloured pill, but it also comes in a variety of other shapes and colours, and is sometimes manufactured as a white pill. This is commonplace, and, as with many types of generic medication, you may find that the appearance of your pills sometimes changes each time you order them. However, don’t worry